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Nanomaterials 2017, 7(1), 2; doi:10.3390/nano7010002

Visible Light-Responsive Platinum-Containing Titania Nanoparticle-Mediated Photocatalysis Induces Nucleotide Insertion, Deletion and Substitution Mutations

1
Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 97004, Taiwan
2
Nanobiomedical Research Center, Tzu-Chi University, Hualien 97004, Taiwan
3
Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
4
Department of Materials Science and Engineering, National Dong-Hwa University, Hualien 97401, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Guogang Ren
Received: 14 October 2016 / Revised: 8 December 2016 / Accepted: 22 December 2016 / Published: 28 December 2016
(This article belongs to the Special Issue Antimicrobial Nanomaterials and Nanotechnology)
View Full-Text   |   Download PDF [2583 KB, uploaded 28 December 2016]   |  

Abstract

Conventional photocatalysts are primarily stimulated using ultraviolet (UV) light to elicit reactive oxygen species and have wide applications in environmental and energy fields, including self-cleaning surfaces and sterilization. Because UV illumination is hazardous to humans, visible light-responsive photocatalysts (VLRPs) were discovered and are now applied to increase photocatalysis. However, fundamental questions regarding the ability of VLRPs to trigger DNA mutations and the mutation types it elicits remain elusive. Here, through plasmid transformation and β-galactosidase α-complementation analyses, we observed that visible light-responsive platinum-containing titania (TiO2) nanoparticle (NP)-mediated photocatalysis considerably reduces the number of Escherichia coli transformants. This suggests that such photocatalytic reactions cause DNA damage. DNA sequencing results demonstrated that the DNA damage comprises three mutation types, namely nucleotide insertion, deletion and substitution; this is the first study to report the types of mutations occurring after photocatalysis by TiO2-VLRPs. Our results may facilitate the development and appropriate use of new-generation TiO2 NPs for biomedical applications. View Full-Text
Keywords: visible light-responsive photocatalyst; TiO2; nanoparticle; DNA mutation; lacZ α-complementation visible light-responsive photocatalyst; TiO2; nanoparticle; DNA mutation; lacZ α-complementation
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Sun, D.-S.; Tseng, Y.-H.; Wu, W.-S.; Wong, M.-S.; Chang, H.-H. Visible Light-Responsive Platinum-Containing Titania Nanoparticle-Mediated Photocatalysis Induces Nucleotide Insertion, Deletion and Substitution Mutations. Nanomaterials 2017, 7, 2.

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