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J. Funct. Biomater. 2012, 3(4), 706-725; doi:10.3390/jfb3040706
Article

Cytocompatibility and Mechanical Properties of Short Phosphate Glass Fibre Reinforced Polylactic Acid (PLA) Composites: Effect of Coupling Agent Mediated Interface

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 and *
Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, UK
* Author to whom correspondence should be addressed.
Received: 19 April 2012 / Revised: 12 July 2012 / Accepted: 27 September 2012 / Published: 16 October 2012
(This article belongs to the Special Issue Biocompatibility of Biomaterials)
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Abstract

In this study three chemical agents Amino-propyl-triethoxy-silane (APS), sorbitol ended PLA oligomer (SPLA) and Hexamethylene diisocyanate (HDI) were identified to be used as coupling agents to react with the phosphate glass fibre (PGF) reinforcement and the polylactic acid (PLA) polymer matrix of the composite. Composites were prepared with short chopped strand fibres (l = 20 mm, ϕ = 20 µm) in a random arrangement within PLA matrix. Improved, initial composite flexural strength (~20 MPa) was observed for APS treated fibres, which was suggested to be due to enhanced bonding between the fibres and polymer matrix. Both APS and HDI treated fibres were suggested to be covalently linked with the PLA matrix. The hydrophobicity induced by these coupling agents (HDI, APS) helped to resist hydrolysis of the interface and thus retained their mechanical properties for an extended period of time as compared to non-treated control. Approximately 70% of initial strength and 65% of initial modulus was retained by HDI treated fibre composites in contrast to the control, where only ~50% of strength and modulus was retained after 28 days of immersion in PBS at 37 °C. All coupling agent treated and control composites demonstrated good cytocompatibility which was comparable to the tissue culture polystyrene (TCP) control, supporting the use of these materials as coupling agent’s within medical implant devices.
Keywords: phosphate glass; fibre; PLA; composite; degradation; cytocompatibility; mechanical properties; coupling agent phosphate glass; fibre; PLA; composite; degradation; cytocompatibility; mechanical properties; coupling agent
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hasan, M.S.; Ahmed, I.; Parsons, A.; Walker, G.; Scotchford, C. Cytocompatibility and Mechanical Properties of Short Phosphate Glass Fibre Reinforced Polylactic Acid (PLA) Composites: Effect of Coupling Agent Mediated Interface. J. Funct. Biomater. 2012, 3, 706-725.

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