Special Issue "Biocompatibility of Biomaterials"
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).
Deadline for manuscript submissions: closed (30 June 2012)
The concept of "biocompatibility" underpins all of the development and application of biomaterials, as materials that are not safe and fit for their intended purpose are clearly unsuitable for clinical use. With the increasing use of biomaterials and related technologies that interact with host tissues to achieve a performance benefit, the evaluation of biocompatibility is becoming both more important and more challenging. Indeed, the combination of newly-available medical technologies and increased need for cost-effective clinical intervention is driving unprecedented change in biomaterials science, and there is today a greater need than ever before to develop good predictive models of biocompatibility. In vitro testing is now often very complex, with the development of co-cultured cell constructs and bioreactors that can mimic some of the complexity of the whole organism. In vivo models too have increased in sophistication, with genetically engineered animals that can communicate specific physiological changes via detectable signals such as fluorescence. Finally, many new analytical technologies, for example Raman microscopy, are being adopted from other fields and applied to the study of biochemical events that are related closely to biocompatibility. The aim of this special issue is to consider all aspects of biocompatibility testing, with a particular emphasis on the development and use of new technologies for this purpose.
Prof. Dr. Paul V. Hatton
- in vitro testing
- in vivo testing