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J. Funct. Biomater. 2012, 3(2), 269-282; doi:10.3390/jfb3020269
Article

Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices

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Received: 29 February 2012 / Revised: 21 March 2012 / Accepted: 22 March 2012 / Published: 29 March 2012
(This article belongs to the Special Issue Molecularly Imprinted Polymers in Biomedical Applications)
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Abstract

In this work, molecularly imprinted nanospheres for controlled/sustained release of quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylate as functional monomer and crosslinking agent, respectively. One pot precipitation polymerization was chosen as polymerization technique to obtain nanosized materials with spherical shape. Morphological and hydrophilic properties by scanning electron microscopy and water content measurements were determined, and recognition and selectivity properties of the imprinted materials were tested using the template quercetin and its structural analogue, the flavonoid catechin. Finally, the applicability of the obtained materials as drug delivery devices was evaluated by performing in vitro release studies in plasma simulating fluids and cytotoxicity testson HeLa cells.
Keywords: molecularly imprinted polymers; quercetin; drug delivery; cytotoxicity test; nanomaterials molecularly imprinted polymers; quercetin; drug delivery; cytotoxicity test; nanomaterials
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Picci, N.; Puoci, F. Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices. J. Funct. Biomater. 2012, 3, 269-282.

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