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Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices
Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS) 87036, Italy
* Author to whom correspondence should be addressed.
Received: 29 February 2012; in revised form: 21 March 2012 / Accepted: 22 March 2012 / Published: 29 March 2012
Abstract: In this work, molecularly imprinted nanospheres for controlled/sustained release of quercetin were synthesized employing methacrylic acid and ethylene glycoldymethacrylate as functional monomer and crosslinking agent, respectively. One pot precipitation polymerization was chosen as polymerization technique to obtain nanosized materials with spherical shape. Morphological and hydrophilic properties by scanning electron microscopy and water content measurements were determined, and recognition and selectivity properties of the imprinted materials were tested using the template quercetin and its structural analogue, the flavonoid catechin. Finally, the applicability of the obtained materials as drug delivery devices was evaluated by performing in vitro release studies in plasma simulating fluids and cytotoxicity testson HeLa cells.
Keywords: molecularly imprinted polymers; quercetin; drug delivery; cytotoxicity test; nanomaterials
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Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Picci, N.; Puoci, F. Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices. J. Funct. Biomater. 2012, 3, 269-282.
Curcio M, Cirillo G, Parisi OI, Iemma F, Picci N, Puoci F. Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices. Journal of Functional Biomaterials. 2012; 3(2):269-282.
Curcio, Manuela; Cirillo, Giuseppe; Parisi, Ortensia Ilaria; Iemma, Francesca; Picci, Nevio; Puoci, Francesco. 2012. "Quercetin-Imprinted Nanospheres as Novel Drug Delivery Devices." J. Funct. Biomater. 3, no. 2: 269-282.