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Vaccines 2016, 4(4), 36; doi:10.3390/vaccines4040036

The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression

1
Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany
2
Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim 68167, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Theresa L. Whiteside
Received: 15 August 2016 / Revised: 4 October 2016 / Accepted: 31 October 2016 / Published: 3 November 2016
(This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
View Full-Text   |   Download PDF [1131 KB, uploaded 3 November 2016]   |  

Abstract

The immunosuppressive tumor microenvironment represents not only one of the key factors stimulating tumor progression but also a strong obstacle for efficient tumor immunotherapy. Immunosuppression was found to be associated with chronic inflammatory mediators including cytokines, chemokines and growth factors produced by cancer and stroma cells. Long-term intensive production of these factors induces the formation of myeloid-derived suppressor cells (MDSCs) representing one of the most important players mediating immunosuppression. Moreover, MDSCs could not only inhibit anti-tumor immune reactions but also directly stimulate tumor growth and metastasis. Therefore, understanding the mechanisms of their generation, expansion, recruitment and activation is required for the development of novel strategies for tumor immunotherapy. View Full-Text
Keywords: myeloid-derived suppressor cells; myelopoiesis; tumor microenvironment; immunosuppression; therapeutic targeting myeloid-derived suppressor cells; myelopoiesis; tumor microenvironment; immunosuppression; therapeutic targeting
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Umansky, V.; Blattner, C.; Gebhardt, C.; Utikal, J. The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression. Vaccines 2016, 4, 36.

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