Next Article in Journal / Special Issue
The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression
Previous Article in Journal
Influenza and Memory T Cells: How to Awake the Force
Previous Article in Special Issue
Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy
Article Menu

Export Article

Open AccessReview
Vaccines 2016, 4(4), 35; doi:10.3390/vaccines4040035

Tumor-Derived Exosomes and Their Role in Tumor-Induced Immune Suppression

University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1.32, Pittsburgh, PA 15213, USA
Academic Editor: C.A.H.H. Daemen
Received: 16 August 2016 / Revised: 12 September 2016 / Accepted: 28 September 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
View Full-Text   |   Download PDF [1607 KB, uploaded 20 October 2016]   |  

Abstract

Tumor-derived exosomes (TEX) are emerging as critical components of an intercellular information network between the tumor and the host. The tumor escapes from the host immune system by using a variety of mechanisms designed to impair or eliminate anti-tumor immunity. TEX carrying a cargo of immunoinhibitory molecules and factors represent one such mechanism. TEX, which are present in all body fluids of cancer patients, deliver negative molecular or genetic signals to immune cells re-programming their functions. Although TEX can also stimulate immune activity, in the microenvironments dominated by the tumor, TEX tend to mediate immune suppression thus promoting tumor progression. The TEX content, in part resembling that of the parent cell, may serve as a source of cancer biomarkers. TEX also interfere with immune therapies. A better understanding of TEX and their contribution to cancer progression and cancer patients’ response to immune therapies represents a challenging new field of investigation. View Full-Text
Keywords: cancer; tumor-derived exosomes; TEX; immune suppression; biomarkers cancer; tumor-derived exosomes; TEX; immune suppression; biomarkers
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Whiteside, T.L. Tumor-Derived Exosomes and Their Role in Tumor-Induced Immune Suppression. Vaccines 2016, 4, 35.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top