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Vaccines 2016, 4(3), 31; doi:10.3390/vaccines4030031

Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy

Department of Microbiology Immunology, University of Miami, Miami, FL 33146, USA
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Author to whom correspondence should be addressed.
Academic Editor: Theresa L. Whiteside
Received: 14 July 2016 / Revised: 2 September 2016 / Accepted: 7 September 2016 / Published: 9 September 2016
(This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
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Abstract

Neutrophils are the most abundant circulating blood cell type in humans, and are the first white blood cells recruited at the inflammation site where they orchestrate the initial immune response. Although their presence at the tumor site was recognized in the 1970s, until recently these cells have been neglected and considered to play just a neutral role in tumor progression. Indeed, in recent years neutrophils have been recognized to play a dual role in tumor development by either assisting the growth, angiogenesis, invasion, and metastasis or by exerting tumoricidal action directly via the secretion of antitumoral compounds, or indirectly via the orchestration of antitumor immunity. Understanding the biology of these cells and influencing their polarization in the tumor micro- and macro-environment may be the key for the development of new therapeutic strategies, which may finally hold the promise of an effective immunotherapy for cancer. View Full-Text
Keywords: gMDSC; neutrophils; cancer; immunotherapy; sex gMDSC; neutrophils; cancer; immunotherapy; sex
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zilio, S.; Serafini, P. Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy. Vaccines 2016, 4, 31.

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