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Insects 2013, 4(4), 593-608; doi:10.3390/insects4040593
Article

Exploring the Role of Rhodtestolin, A Cardio-Inhibitor from the Testes of Rhodnius prolixus, in Relation to the Structure and Function of Reproductive Organs in Insect Vectors of Chagas Disease

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Received: 31 August 2013; in revised form: 8 October 2013 / Accepted: 21 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue Feature Papers 2013)
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Abstract: Rhodtestolin is a cardio-inhibitor that was first discovered in testes extracts of the blood-feeding insect, Rhodnius prolixus. Its role in reproduction remains unconfirmed, but if delivered to the female during spermatophore formation, it may serve to calm the female and/or relax the vaginal muscles to facilitate delivery and storage of the spermatophore. We describe here the anatomy of reproductive organs in R. prolixus and show that rhodtestolin is present in a low-molecular weight fraction of testes extracts separated by gel filtration, as well as in spermatophores delivered to the female during spermatophore formation. We also report that a rhodtestolin-like factor is present in the testes of R. brethesi, Triatoma dimidiata, T. klugi and Nesotriatoma bruneri, other Reduviidae, which are vectors of Chagas disease. Male secretions in insects are known to modify female behavior after copulation, and the presence of rhodtestolin in several genera of Reduviidae suggests that it plays an important role in reproductive success. Determining this role could lead to developing additional population control strategies for these bugs.
Keywords: Reduviidae; Triatominae; Rhodnius; cardio-inhibitor; rhodtestolin; testes extracts; spermatophore; insect reproduction; Chagas disease Reduviidae; Triatominae; Rhodnius; cardio-inhibitor; rhodtestolin; testes extracts; spermatophore; insect reproduction; Chagas disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chiang, R.G.; Chiang, J.A.; Hoogendoorn, H.; Lima, M.M. Exploring the Role of Rhodtestolin, A Cardio-Inhibitor from the Testes of Rhodnius prolixus, in Relation to the Structure and Function of Reproductive Organs in Insect Vectors of Chagas Disease. Insects 2013, 4, 593-608.

AMA Style

Chiang RG, Chiang JA, Hoogendoorn H, Lima MM. Exploring the Role of Rhodtestolin, A Cardio-Inhibitor from the Testes of Rhodnius prolixus, in Relation to the Structure and Function of Reproductive Organs in Insect Vectors of Chagas Disease. Insects. 2013; 4(4):593-608.

Chicago/Turabian Style

Chiang, Ralem G.; Chiang, Jennifer A.; Hoogendoorn, Hugh; Lima, Marli M. 2013. "Exploring the Role of Rhodtestolin, A Cardio-Inhibitor from the Testes of Rhodnius prolixus, in Relation to the Structure and Function of Reproductive Organs in Insect Vectors of Chagas Disease." Insects 4, no. 4: 593-608.

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