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Genes 2015, 6(3), 469-483; doi:10.3390/genes6030469

From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA
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Author to whom correspondence should be addressed.
Academic Editor: Jessica Tyler
Received: 23 April 2015 / Revised: 8 June 2015 / Accepted: 24 June 2015 / Published: 30 June 2015
(This article belongs to the Special Issue Chromatin Dynamics)
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Abstract

Transcriptional activation of eukaryotic genes is accompanied, in general, by a change in the sensitivity of promoter chromatin to endonucleases. The structural basis of this alteration has remained elusive for decades; but the change has been viewed as a transformation of one structure into another, from “closed” to “open” chromatin. In contradistinction to this static and deterministic view of the problem, a dynamical and probabilistic theory of promoter chromatin has emerged as its solution. This theory, which we review here, explains observed variation in promoter chromatin structure at the level of single gene molecules and provides a molecular basis for random bursting in transcription—the conjecture that promoters stochastically transition between transcriptionally conducive and inconducive states. The mechanism of transcriptional regulation may be understood only in probabilistic terms. View Full-Text
Keywords: chromatin dynamics; transcriptional bursting; gene expression noise; stochastic process chromatin dynamics; transcriptional bursting; gene expression noise; stochastic process
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Boeger, H.; Shelansky, R.; Patel, H.; Brown, C.R. From Structural Variation of Gene Molecules to Chromatin Dynamics and Transcriptional Bursting. Genes 2015, 6, 469-483.

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