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Genes 2015, 6(3), 451-468; doi:10.3390/genes6030451

Regulation of Unperturbed DNA Replication by Ubiquitylation

School of Cancer Sciences, University of Birmingham, Vincent Drive, B15 2TT, Birmingham, UK
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Author to whom correspondence should be addressed.
Academic Editor: Peter Frank
Received: 16 April 2015 / Revised: 5 June 2015 / Accepted: 16 June 2015 / Published: 25 June 2015
(This article belongs to the Special Issue DNA Replication)
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Abstract

Posttranslational modification of proteins by means of attachment of a small globular protein ubiquitin (i.e., ubiquitylation) represents one of the most abundant and versatile mechanisms of protein regulation employed by eukaryotic cells. Ubiquitylation influences almost every cellular process and its key role in coordination of the DNA damage response is well established. In this review we focus, however, on the ways ubiquitylation controls the process of unperturbed DNA replication. We summarise the accumulated knowledge showing the leading role of ubiquitin driven protein degradation in setting up conditions favourable for replication origin licensing and S-phase entry. Importantly, we also present the emerging major role of ubiquitylation in coordination of the active DNA replication process: preventing re-replication, regulating the progression of DNA replication forks, chromatin re-establishment and disassembly of the replisome at the termination of replication forks. View Full-Text
Keywords: DNA replication; ubiquitylation; proteasomal degradation; re-replication; termination; posttranslational modification; replisome DNA replication; ubiquitylation; proteasomal degradation; re-replication; termination; posttranslational modification; replisome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Moreno, S.P.; Gambus, A. Regulation of Unperturbed DNA Replication by Ubiquitylation. Genes 2015, 6, 451-468.

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