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Genes 2015, 6(2), 353-371; doi:10.3390/genes6020353

The Fork in the Road: Histone Partitioning During DNA Replication

Biology Department, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA
Academic Editor: Jessica Tyler
Received: 1 May 2015 / Revised: 15 June 2015 / Accepted: 16 June 2015 / Published: 23 June 2015
(This article belongs to the Special Issue Chromatin Dynamics)
View Full-Text   |   Download PDF [128 KB, uploaded 23 June 2015]

Abstract

In the following discussion the distribution of histones at the replication fork is examined, with specific attention paid to the question of H3/H4 tetramer "splitting." After a presentation of early experiments surrounding this topic, more recent contributions are detailed. The implications of these findings with respect to the transmission of histone modifications and epigenetic models are also addressed. View Full-Text
Keywords: chromatin; nucleosome; tetramer; histone; acetylation; methylation; replication; splitting; epigenetics chromatin; nucleosome; tetramer; histone; acetylation; methylation; replication; splitting; epigenetics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Annunziato, A.T. The Fork in the Road: Histone Partitioning During DNA Replication. Genes 2015, 6, 353-371.

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