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Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis
Autoimmunity Laboratory, Centre for Inflammatory Diseases, Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria 3168, Australia
Diabetes and Metabolism Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, Victoria 3004, Australia
* Author to whom correspondence should be addressed.
Received: 5 August 2010; in revised form: 3 September 2010 / Accepted: 17 September 2010 / Published: 30 September 2010
Abstract: Cell Division Autoantigen 1 (CDA1) was discovered following screening a human expression library with serum from a patient with Discoid Lupus Erythematosus. CDA1, encoded by TSPYL2 on the X chromosome, shares anti-proliferative and pro‑fibrotic properties with TGF-b. It inhibits cell growth through p53, pERK1/2 and p21‑mediated pathways and is implicated in tumorigenesis and the DNA damage response. Its pro-fibrotic property is mediated through cross-talk with TGF-b that results in upregulation of extracellular matrix proteins. The latter properties have identified a key role for CDA1 in diabetes associated atherosclerosis. These dual properties place CDA1 as an attractive molecular target for treating tumors and vascular fibrosis including atherosclerosis and other vascular disorders associated with enhanced TGF-β action and tissue scarring.
Keywords: TGF-b; tumorigenesis; DNA damage; atherosclerosis; diabetes mellitus
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MDPI and ACS Style
Toh, B.-H.; Tu, Y.; Cao, Z.; Cooper, M.E.; Chai, Z. Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis. Genes 2010, 1, 335-348.
Toh B-H, Tu Y, Cao Z, Cooper ME, Chai Z. Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis. Genes. 2010; 1(3):335-348.
Toh, Ban-Hock; Tu, Yugang; Cao, Zemin; Cooper, Mark E.; Chai, Zhonglin. 2010. "Role of Cell Division Autoantigen 1 (CDA1) in Cell Proliferation and Fibrosis." Genes 1, no. 3: 335-348.