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Transgenic Mouse Studies to Understand the Regulation, Expression and Function of the Testis-Specific Protein Y-Encoded (TSPY) Gene
Genes 2010, 1(2), 283-293; doi:10.3390/genes1020283
Article

Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer

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Received: 9 August 2010; in revised form: 1 September 2010 / Accepted: 2 September 2010 / Published: 14 September 2010
(This article belongs to the Special Issue The TSPY Gene Family)
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Abstract: TSPY is a Y-encoded gene that is expressed in normal testicular germ cells and various cancer types including germ cell tumor, melanoma, hepatocellular carcinoma, and prostate cancer. Currently, the correlation between TSPY expression and oncogenic development has not been established, particularly in somatic cancers. To establish such correlation, we analyzed the expression of TSPY, in reference to its interactive oncoprotein, EEF1A, tumor biomarker, AMACR, and normal basal cell biomarker, p63, in 41 cases of clinical prostate cancers (CPCa), 17 cases of latent prostate cancers (LPCa), and 19 cases of non-cancerous prostate (control) by immunohistochemistry. Our results show that TSPY was detected more frequently (78%) in the clinical prostate cancer specimens than those of latent prostate cancer (47%) and control (50%). In the latent cancer group, the levels of TSPY expression could be correlated with increasing Gleason grades. TSPY expression was detected in seven out of nine high-grade latent cancer samples (Gleason 7 and more). The expression of the TSPY binding partner EEF1A was detectable in all prostate specimens, but the levels were higher in cancer cells in clinical and latent prostate cancer specimens than normal prostatic cells. These observations suggest that expressions of TSPY and its binding partner EEF1A are associated with the development and progression of prostate cancer.
Keywords: prostate cancer; TSPY; EEF1A; latent cancer; clinical cancer prostate cancer; TSPY; EEF1A; latent cancer; clinical cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kido, T.; Hatakeyama, S.; Ohyama, C.; Lau, Y.-F. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes 2010, 1, 283-293.

AMA Style

Kido T, Hatakeyama S, Ohyama C, Lau Y-F. Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer. Genes. 2010; 1(2):283-293.

Chicago/Turabian Style

Kido, Tatsuo; Hatakeyama, Shingo; Ohyama, Chikara; Lau, Yun-Fai Chris. 2010. "Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer." Genes 1, no. 2: 283-293.


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