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An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs. CB10 1SA, UK
* Author to whom correspondence should be addressed.
Received: 24 November 2010; in revised form: 24 December 2010 / Accepted: 28 December 2010 / Published: 10 January 2011
Abstract: The TSPY gene stands out from all other human protein-coding genes because of its high copy number and tandemly-repeated organization. Here, we review its evolutionary history in great apes in order to assess whether these unusual properties are more likely to result from a relaxation of constraint or an unusual functional role. Detailed comparisons with chimpanzee are possible because a finished sequence of the chimpanzee Y chromosome is available, together with more limited data from other apes. These comparisons suggest that the human-chimpanzee ancestral Y chromosome carried a tandem array of TSPY genes which expanded on the human lineage while undergoing multiple duplication events followed by pseudogene formation on the chimpanzee lineage. The protein coding region is the most highly conserved of the multi-copy Y genes in human-chimpanzee comparisons, and the analysis of the dN/dS ratio indicates that TSPY is evolutionarily highly constrained, but may have experienced positive selection after the human-chimpanzee split. We therefore conclude that the exceptionally high copy number in humans is most likely due to a human-specific but unknown functional role, possibly involving rapid production of a large amount of TSPY protein at some stage during spermatogenesis.
Keywords: TSPY; Y chromosome; great ape; human; evolution
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Cite This Article
MDPI and ACS Style
Xue, Y.; Tyler-Smith, C. An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes. Genes 2011, 2, 36-47.
Xue Y, Tyler-Smith C. An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes. Genes. 2011; 2(1):36-47.
Xue, Yali; Tyler-Smith, Chris. 2011. "An Exceptional Gene: Evolution of the TSPY Gene Family in Humans and Other Great Apes." Genes 2, no. 1: 36-47.