Table of Contents
Cancers, Volume 9, Issue 10 (October 2017)
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Cover Story Alcohol consumption is associated with a large number of chronic diseases and deaths worldwide. [...] Read more. Alcohol consumption is associated with a large number of chronic diseases and deaths worldwide. About 10% of all cancer cases in men and 3% in women are estimated to be attributable to alcohol abuse, with a high impact on the liver where it seems to be responsible for 20–30% of hepatic cancers in both genders. Although it is known that most of the cytotoxic effects of alcohol depend on metabolites generating from its hepatic catabolism, new evidence emerged for the characterization of genetic, epigenetic and environmental factors that synergistically influence liver injury enabling tumor development. View the paper