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Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame

1
Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany
2
Department of Immunology, Complutense University School of Medicine, Madrid 28040, Spain
3
13 de Octubre Health Research Institute (imas12), Madrid 28041, Spain
4
Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Helmut K. Seitz and Sebastian Mueller
Cancers 2017, 9(10), 130; https://doi.org/10.3390/cancers9100130
Received: 14 August 2017 / Revised: 15 September 2017 / Accepted: 19 September 2017 / Published: 25 September 2017
(This article belongs to the Special Issue Alcohol and Cancer)
Primary tumors of the liver represent the fifth most common type of cancer in the world and the third leading cause of cancer-related death. Case-control studies from different countries report that chronic ethanol consumption is associated with an approximately 2-fold increased odds ratio for hepatocellular carcinoma (HCC). Despite the substantial epidemiologic data in humans demonstrating that chronic alcohol consumption is a major risk factor for HCC development, the pathways causing alcohol-induced liver cancer are poorly understood. In this overview, we summarize the epidemiological evidence for the association between alcohol and liver cancer, review the genetic, oncogenic, and epigenetic factors that drive HCC development synergistically with ethanol intake and discuss the essential molecular and metabolic pathways involved in alcohol-induced liver tumorigenesis. View Full-Text
Keywords: alcohol; hepatocellular carcinoma; acetaldehyde; oxidative stress; apoptosis alcohol; hepatocellular carcinoma; acetaldehyde; oxidative stress; apoptosis
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MDPI and ACS Style

Ramadori, P.; Cubero, F.J.; Liedtke, C.; Trautwein, C.; Nevzorova, Y.A. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers 2017, 9, 130. https://doi.org/10.3390/cancers9100130

AMA Style

Ramadori P, Cubero FJ, Liedtke C, Trautwein C, Nevzorova YA. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers. 2017; 9(10):130. https://doi.org/10.3390/cancers9100130

Chicago/Turabian Style

Ramadori, Pierluigi, Francisco J. Cubero, Christian Liedtke, Christian Trautwein, and Yulia A. Nevzorova. 2017. "Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame" Cancers 9, no. 10: 130. https://doi.org/10.3390/cancers9100130

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