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Cancers 2017, 9(10), 130; doi:10.3390/cancers9100130

Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame

1
Department of Internal Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany
2
Department of Immunology, Complutense University School of Medicine, Madrid 28040, Spain
3
13 de Octubre Health Research Institute (imas12), Madrid 28041, Spain
4
Department of Animal Physiology II, Faculty of Biology, Complutense University, Madrid 28040, Spain
*
Authors to whom correspondence should be addressed.
Academic Editors: Helmut K. Seitz and Sebastian Mueller
Received: 14 August 2017 / Revised: 15 September 2017 / Accepted: 19 September 2017 / Published: 25 September 2017
(This article belongs to the Special Issue Alcohol and Cancer)
View Full-Text   |   Download PDF [1416 KB, uploaded 27 September 2017]   |  

Abstract

Primary tumors of the liver represent the fifth most common type of cancer in the world and the third leading cause of cancer-related death. Case-control studies from different countries report that chronic ethanol consumption is associated with an approximately 2-fold increased odds ratio for hepatocellular carcinoma (HCC). Despite the substantial epidemiologic data in humans demonstrating that chronic alcohol consumption is a major risk factor for HCC development, the pathways causing alcohol-induced liver cancer are poorly understood. In this overview, we summarize the epidemiological evidence for the association between alcohol and liver cancer, review the genetic, oncogenic, and epigenetic factors that drive HCC development synergistically with ethanol intake and discuss the essential molecular and metabolic pathways involved in alcohol-induced liver tumorigenesis. View Full-Text
Keywords: alcohol; hepatocellular carcinoma; acetaldehyde; oxidative stress; apoptosis alcohol; hepatocellular carcinoma; acetaldehyde; oxidative stress; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ramadori, P.; Cubero, F.J.; Liedtke, C.; Trautwein, C.; Nevzorova, Y.A. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers 2017, 9, 130.

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