Next Article in Journal
Assessment of Hypoxia in the Stroma of Patient-Derived Pancreatic Tumor Xenografts
Previous Article in Journal
Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression
Previous Article in Special Issue
Chemoprevention of Breast Cancer: The Paradox of Evidence versus Advocacy Inaction
Cancers 2014, 6(1), 436-458; doi:10.3390/cancers6010436
Review

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment

1
, 1
 and 2,*
Received: 18 December 2013; in revised form: 10 January 2014 / Accepted: 7 February 2014 / Published: 26 February 2014
(This article belongs to the Special Issue Advances in Cancer Chemoprevention)
View Full-Text   |   Download PDF [575 KB, uploaded 26 February 2014]   |   Browse Figure
Abstract: For more than four decades, the cyclic nucleotides cyclic AMP (cAMP) and cyclic GMP (cGMP) have been recognized as important signaling molecules within cells. Under normal physiological conditions, cyclic nucleotides regulate a myriad of biological processes such as cell growth and adhesion, energy homeostasis, neuronal signaling, and muscle relaxation. In addition, altered cyclic nucleotide signaling has been observed in a number of pathophysiological conditions, including cancer. While the distinct molecular alterations responsible for these effects vary depending on the specific cancer type, several studies have demonstrated that activation of cyclic nucleotide signaling through one of three mechanisms—induction of cyclic nucleotide synthesis, inhibition of cyclic nucleotide degradation, or activation of cyclic nucleotide receptors—is sufficient to inhibit proliferation and activate apoptosis in many types of cancer cells. These findings suggest that targeting cyclic nucleotide signaling can provide a strategy for the discovery of novel agents for the prevention and/or treatment of selected cancers.
Keywords: cyclic nucleotides; cAMP; cGMP; cyclic nucleotide phosphodiesterases; protein kinases; PKG; PKA cyclic nucleotides; cAMP; cGMP; cyclic nucleotide phosphodiesterases; protein kinases; PKG; PKA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Fajardo, A.M.; Piazza, G.A.; Tinsley, H.N. The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment. Cancers 2014, 6, 436-458.

AMA Style

Fajardo AM, Piazza GA, Tinsley HN. The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment. Cancers. 2014; 6(1):436-458.

Chicago/Turabian Style

Fajardo, Alexandra M.; Piazza, Gary A.; Tinsley, Heather N. 2014. "The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment." Cancers 6, no. 1: 436-458.


Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert