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Cancers 2011, 3(1), 841-871; doi:10.3390/cancers3010841

Growth Factor Mediated Signaling in Pancreatic Pathogenesis

Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, 200 First Street SW, Guggenheim 1321C, Rochester, MN 55905, USA
* Author to whom correspondence should be addressed.
Received: 26 January 2011 / Revised: 12 February 2011 / Accepted: 16 February 2011 / Published: 24 February 2011
(This article belongs to the Special Issue Pancreatic Cancer)
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Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed.
Keywords: growth factors; signaling; pancreatitis; pancreatic carcinoma growth factors; signaling; pancreatitis; pancreatic carcinoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nandy, D.; Mukhopadhyay, D. Growth Factor Mediated Signaling in Pancreatic Pathogenesis. Cancers 2011, 3, 841-871.

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