Cancers 2011, 3(1), 1454-1466; doi:10.3390/cancers3011454
Case Report

Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report

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Received: 7 January 2011; Accepted: 21 February 2011 / Published: 17 March 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The present article describes the ongoing (partial) remission of a female patient (41 years old) from estrogen receptor (ER)-positive/progesterone receptor (PR)-negative metastatic breast cancer in response to a combination treatment directed towards the revitalization of the mitochondrial respiratory chain (oxidative phosphorylation), the suppression of NF-kappaB as a factor triggering the inflammatory response, and chemotherapy with capecitabine. The reduction of tumor mass was evidenced by a continuing decline of CA15-3 and CEA tumor marker serum levels and 18FDG-PET-CT plus magnetic resonance (MR) imaging. It is concluded that such combination treatment might be a useful option for treating already formed metastases and for providing protection against the formation of metastases in ER positive breast cancer. The findings need to be corroborated by clinical trials. Whether similar results can be expected for other malignant tumor phenotypes relying on glycolysis as the main energy source remains to be elucidated.
Keywords: breast cancer; chemotherapy; respiratory chain; Warburg effect; inflammatory chain; partial remission
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MDPI and ACS Style

Meiners, C. Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report. Cancers 2011, 3, 1454-1466.

AMA Style

Meiners C. Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report. Cancers. 2011; 3(1):1454-1466.

Chicago/Turabian Style

Meiners, Christian. 2011. "Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report." Cancers 3, no. 1: 1454-1466.

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