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• Krantz, S
• Shields, M
• Dangi-Garimella, S
• Bentrem, D
• Munshi, H
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• Krantz, S
• Shields, M
• Dangi-Garimella, S
• Bentrem, D
• Munshi, H
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• Shields, M
• Dangi-Garimella, S
• Bentrem, D
• Munshi, H

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Cancers 2010, 2(4), 2084-2097; doi:10.3390/cancers2042084

Review

Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression

Seth B. Krantz ^1,* , Mario A. Shields ² , Surabhi Dangi-Garimella ² , David J. Bentrem ^1,3,4  and Hidayatullah G. Munshi ^2,3,4,*

¹ Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ² Departments of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ³ Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ⁴ Jesse Brown VA Medical Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60612, USA

* Authors to whom correspondence should be addressed.

Received: 24 October 2010; in revised form: 1 December 2010 / Accepted: 1 December 2010 / Published: 9 December 2010

(This article belongs to the Special Issue Pancreatic Cancer)

Download PDF Full-Text [292 KB, uploaded 9 December 2010 14:19 CET]

Abstract: Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer.

Keywords: pancreatic cancer; epithelial-mesenchymal transition microRNA; stem cells drug resistance

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