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Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
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Cancers 2010, 2(4), 2084-2097; doi:10.3390/cancers2042084

Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression

1
Departments of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
2
Departments of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
3
Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
4
Jesse Brown VA Medical Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60612, USA
*
Authors to whom correspondence should be addressed.
Received: 24 October 2010 / Revised: 1 December 2010 / Accepted: 1 December 2010 / Published: 9 December 2010
(This article belongs to the Special Issue Pancreatic Cancer)
View Full-Text   |   Download PDF [292 KB, uploaded 9 December 2010]   |  

Abstract

Pancreatic adenocarcinoma (PDAC) is one of the most lethal human malignancies, with median survival of less than one year and overall five-year survival of less than 5%. There is increasing evidence demonstrating that epithelial-mesenchymal transition (EMT) contributes to pancreatic cancer metastasis and to treatment resistance. In this review, we will examine the data demonstrating the role and regulation of EMT in pancreatic cancer progression, focusing particularly on the transcription factors and microRNAs involved in EMT. We will examine how EMT is involved in the generation and maintenance of stem cells, and the role of EMT in modulating resistance of PDAC cells to drug therapies. We will also identify putative EMT-targeting agents that may help to reduce the morbidity and mortality associated with pancreatic cancer. View Full-Text
Keywords: pancreatic cancer; epithelial-mesenchymal transition microRNA; stem cells drug resistance pancreatic cancer; epithelial-mesenchymal transition microRNA; stem cells drug resistance
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Krantz, S.B.; Shields, M.A.; Dangi-Garimella, S.; Bentrem, D.J.; Munshi, H.G. Contribution of Epithelial-Mesenchymal Transition to Pancreatic Cancer Progression. Cancers 2010, 2, 2084-2097.

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