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Epithelial-Mesenchymal Transition in Pancreatic Carcinoma
AbstractPancreatic carcinoma is the fourth-leading cause of cancer death and is characterized by early invasion and metastasis. The developmental program of epithelial-mesenchymal transition (EMT) is of potential importance for this rapid tumor progression. During EMT, tumor cells lose their epithelial characteristics and gain properties of mesenchymal cells, such as enhanced motility and invasive features. This review will discuss recent findings pertinent to EMT in pancreatic carcinoma. Evidence for and molecular characteristics of EMT in pancreatic carcinoma will be outlined, as well as the connection of EMT to related topics, e.g., cancer stem cells and drug resistance.
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Maier, H.J.; Wirth, T.; Beug, H. Epithelial-Mesenchymal Transition in Pancreatic Carcinoma. Cancers 2010, 2, 2058-2083.View more citation formats
Maier HJ, Wirth T, Beug H. Epithelial-Mesenchymal Transition in Pancreatic Carcinoma. Cancers. 2010; 2(4):2058-2083.Chicago/Turabian Style
Maier, Harald J.; Wirth, Thomas; Beug, Hartmut. 2010. "Epithelial-Mesenchymal Transition in Pancreatic Carcinoma." Cancers 2, no. 4: 2058-2083.