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Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections
Institute of Pathology, Technische Universität München, Ismaningerstr. 22, 81675 Munich Germany
Institute of Pathology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
* Author to whom correspondence should be addressed.
Received: 30 October 2010; Accepted: 17 November 2010 / Published: 25 November 2010
Abstract: To date, curative resection is the only chance for cure for patients suffering from pancreatic ductal adenoacarcinoma (PDAC). Despite low reported rates of microscopic tumor infiltration (R1) in most studies, tumor recurrence is a common finding in patients with PDAC and contributes to extremely low long-term survival rates. Lack of international definition of resection margins and of standardized protocols for pathological examination lead to high variation in reported R1 rates. Here we review recent studies supporting the hypothesis that R1 rates are highly underestimated in certain studies and that a microscopic tumor clearance of at least 1 mm is required to confirm radicality and to serve as a reliable prognostic and predictive factor.
Keywords: pancreatic cancer; resection margin; R1; definition of resection status; pathological standardization
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Schlitter, A.M.; Esposito, I. Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections. Cancers 2010, 2, 2001-2010.
Schlitter AM, Esposito I. Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections. Cancers. 2010; 2(4):2001-2010.
Schlitter, Anna Melissa; Esposito, Irene. 2010. "Definition of Microscopic Tumor Clearance (R0) in Pancreatic Cancer Resections." Cancers 2, no. 4: 2001-2010.