Cancers 2010, 2(4), 2026-2043; doi:10.3390/cancers2042026
Review

Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors

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Received: 18 October 2010; in revised form: 9 November 2010 / Accepted: 22 November 2010 / Published: 29 November 2010
(This article belongs to the Special Issue Pancreatic Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer.
Keywords: pancreatic cancer; autophagy; apoptosis; epigenetics; histone deacetylase; ER stress
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MDPI and ACS Style

Rikiishi, H. Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors. Cancers 2010, 2, 2026-2043.

AMA Style

Rikiishi H. Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors. Cancers. 2010; 2(4):2026-2043.

Chicago/Turabian Style

Rikiishi, Hidemi. 2010. "Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors." Cancers 2, no. 4: 2026-2043.

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