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Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors
Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan
Received: 18 October 2010; in revised form: 9 November 2010 / Accepted: 22 November 2010 / Published: 29 November 2010
Abstract: Pancreatic cancer is a lethal disease and notoriously difficult to treat. Only a small proportion is curative by surgical resection, whilst standard chemotherapy for patients with advanced disease has only a modest effect with substantial toxicity. Clearly there is a need for the continual development of novel therapeutic agents to improve the current situation. Currently, there is a bulk of data indicating the important function of autophagy in cancer. While genetic evidence indicates that autophagy functions as a tumor suppressor, it is also apparent that autophagy can promote the survival of established tumors under stress conditions and in response to chemotherapy. This review provides a spectrum of potential pharmacological agents and autophagic approaches to enhance cell killing in pancreatic cancer.
Keywords: pancreatic cancer; autophagy; apoptosis; epigenetics; histone deacetylase; ER stress
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MDPI and ACS Style
Rikiishi, H. Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors. Cancers 2010, 2, 2026-2043.
Rikiishi H. Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors. Cancers. 2010; 2(4):2026-2043.
Rikiishi, Hidemi. 2010. "Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors." Cancers 2, no. 4: 2026-2043.