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Cancers 2010, 2(4), 1884-1894; doi:10.3390/cancers2041884

Nanoparticles in Sentinel Lymph Node Assessment in Breast Cancer

1
Department of Research Oncology, Kings College London, 3rd Floor Bermondsey Wing, Guy’s Hospital, London, SE1 9RT, UK
2
Department of Medical Physics, Guys and St Thomas’ NHS Foundation Trust, 4th Floor Lambeth Wing, St Thomas’ Hospital, London, SE1 7EH, UK
*
Author to whom correspondence should be addressed.
Received: 28 October 2010 / Revised: 2 November 2010 / Accepted: 9 November 2010 / Published: 17 November 2010
(This article belongs to the Special Issue Nanotechnology and Cancer Therapeutics)
View Full-Text   |   Download PDF [228 KB, 3 December 2010; original version 17 November 2010]   |  

Abstract

The modern management of the axilla in breast cancer relies on surgery for accurate staging of disease and identifying those patients at risk who would benefit from adjuvant chemotherapy. The introduction of sentinel lymph node biopsy has revolutionized axillary surgery, but still involves a surgical procedure with associated morbidity in many patients with no axillary involvement. Nanotechnology encompasses a broad spectrum of scientific specialities, of which nanomedicine is one. The potential use of dual-purpose nanoprobes could enable imaging the axilla simultaneous identification and treatment of metastatic disease. Whilst most applications of nanomedicine are still largely in the laboratory phase, some potential applications are currently undergoing clinical evaluation for translation from the bench to the bedside. This is an exciting new area of research where scientific research may become a reality.
Keywords: axillary staging; breast cancer; nanoparticles; sentinel lymph node axillary staging; breast cancer; nanoparticles; sentinel lymph node
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Johnson, L.; Charles-Edwards, G.; Douek, M. Nanoparticles in Sentinel Lymph Node Assessment in Breast Cancer. Cancers 2010, 2, 1884-1894.

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