Cancers 2010, 2(4), 1861-1883; doi:10.3390/cancers2041861

Familial Pancreatic Cancer

1 Department of Preventive Medicine and Public Health, Creighton University, 2500 California Plaza, Omaha NE 68178, USA 2 Department of Gastroenterology, Creighton University, 2500 California Plaza, Omaha NE 68178, USA
* Author to whom correspondence should be addressed.
Received: 12 October 2010; in revised form: 3 November 2010 / Accepted: 4 November 2010 / Published: 10 November 2010
(This article belongs to the Special Issue Pancreatic Cancer)
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Abstract: Pancreatic cancer’s high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for screening and early potential lifesaving diagnosis. Its phenotypic and genotypic heterogeneity is extensive and requires careful scrutiny of its pattern of cancer associations, such as malignant melanoma associated with pancreatic cancer, in the familial atypical multiple mole melanoma syndrome, due to the CDKN2A germline mutation. This review is designed to depict several of the hereditary pancreatic cancer syndromes with particular attention given to the clinical application of this knowledge into improved control of pancreatic cancer.
Keywords: phenotypic and genotypic heterogeneity; high mortality; genetic counseling; biomarker paucity; FAMMM syndrome; Li-Fraumeni syndrome; Lynch syndrome; pancreatic cancer

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MDPI and ACS Style

Lynch, H.T.; Lynch, J.F.; Lanspa, S.J. Familial Pancreatic Cancer. Cancers 2010, 2, 1861-1883.

AMA Style

Lynch HT, Lynch JF, Lanspa SJ. Familial Pancreatic Cancer. Cancers. 2010; 2(4):1861-1883.

Chicago/Turabian Style

Lynch, Henry T.; Lynch, Jane F.; Lanspa, Stephen J. 2010. "Familial Pancreatic Cancer." Cancers 2, no. 4: 1861-1883.

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