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Cancers 2010, 2(4), 1830-1837; doi:10.3390/cancers2041830

Pancreatic Cancer Biomarkers and Their Implication in Cancer Diagnosis and Epidemiology

Methods and Technologies Branch, Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institues of Health (NIH), 6130 Executive Blvd., Suite 5100. Bethesda, MD 20892-7324, USA
Received: 21 October 2010 / Accepted: 29 October 2010 / Published: 2 November 2010
(This article belongs to the Special Issue Pancreatic Cancer)
View Full-Text   |   Download PDF [147 KB, uploaded 2 November 2010]

Abstract

Pancreatic cancer is the fourth most common cause of cancer-related mortality in the United States. Biomarkers are needed to detect this cancer early during the disease development and for screening populations to identify those who are at risk. In cancer, “biomarker” refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis, and epidemiology. A number of potential biomarkers have been identified for pancreatic cancer. These markers can be assayed in non-invasively collected biofluids. These biomarkers need analytical and clinical validation so that they can be used for the purpose of screening and diagnosing pancreatic cancer and determining disease prognosis. In this article, the latest developments in pancreatic cancer biomarkers are discussed. View Full-Text
Keywords: biomarker; cancer; diagnosis; epidemiology; epigenetics; glycans; methylation index; pancreas; prognosis; sensitivity; specificity; survival; treatment biomarker; cancer; diagnosis; epidemiology; epigenetics; glycans; methylation index; pancreas; prognosis; sensitivity; specificity; survival; treatment
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Verma, M. Pancreatic Cancer Biomarkers and Their Implication in Cancer Diagnosis and Epidemiology. Cancers 2010, 2, 1830-1837.

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