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Management of Melanoma Families
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
* Author to whom correspondence should be addressed.
Received: 11 February 2010; in revised form: 12 April 2010 / Accepted: 14 April 2010 / Published: 16 April 2010
Abstract: In this review we have aimed to focus on the clinical management of familial melanoma patients and their relatives. Along this line three major topics will be discussed: (1) management/screening of familial melanoma families: what is advised and what is the evidence thereof; (2) variability of families worldwide with regard to clinical phenotype, including cancer spectrum and likelihood of finding germline mutations and (3) background information for clinicians on the molecular biology of familial melanoma and recent developments in this field.
Keywords: familial melanoma; hereditary melanoma; FAMMM syndrome; pancreatic carcinoma; management; surveillance; screening; DNA testing; CDKN2A
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Bergman, W.; Gruis, N.A. Management of Melanoma Families. Cancers 2010, 2, 549-566.
Bergman W, Gruis NA. Management of Melanoma Families. Cancers. 2010; 2(2):549-566.
Bergman, Wilma; Gruis, Nelleke A. 2010. "Management of Melanoma Families." Cancers 2, no. 2: 549-566.