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Current Research and Development of Chemotherapeutic Agents for Melanoma
Institute of Plant Biology, National Taiwan University, Taipei 106, Taiwan
Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan
Both authors contributed equally to this article.
* Author to whom correspondence should be addressed.
Received: 25 February 2010; in revised form: 25 March 2010 / Accepted: 6 April 2010 / Published: 9 April 2010
Abstract: Cutaneous malignant melanoma is the most lethal form of skin cancer and an increasingly common disease worldwide. It remains one of the most treatment-refractory malignancies. The current treatment options for patients with metastatic melanoma are limited and in most cases non-curative. This review focuses on conventional chemotherapeutic drugs for melanoma treatment, by a single or combinational agent approach, but also summarizes some potential novel phytoagents discovered from dietary vegetables or traditional herbal medicines as alternative options or future medicine for melanoma prevention. We explore the mode of actions of these natural phytoagents against metastatic melanoma.
Keywords: cutaneous malignant melanoma; metastasis; chemotherapeutic drugs; herbal medicines; phytoagents
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Hsan, K.M.; Chen, C.-C.; Shyur, L.-F. Current Research and Development of Chemotherapeutic Agents for Melanoma. Cancers 2010, 2, 397-419.
Hsan KM, Chen C-C, Shyur L-F. Current Research and Development of Chemotherapeutic Agents for Melanoma. Cancers. 2010; 2(2):397-419.
Hsan, Kyaw Minn; Chen, Chun-Chieh; Shyur, Lie-Fen. 2010. "Current Research and Development of Chemotherapeutic Agents for Melanoma." Cancers 2, no. 2: 397-419.