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Cancers 2010, 2(2), 611-623; doi:10.3390/cancers2020611
Article

The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines

1,* , 1
,
1
 and
2
1 Research Laboratory on Neuropeptides, Virgen del Rocío University Hospital, Sevilla, Spain 2 Institute of Neurosciences of Castilla y León (INCYL), Laboratory of Neuroanatomy of the Peptidergic Systems (Laboratory 14), Salamanca, Spain
* Author to whom correspondence should be addressed.
Received: 17 March 2010 / Revised: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
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Abstract

It has been recently demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonists induce cell proliferation and cell inhibition in human melanoma cells, respectively. However, the antitumor action of the NK-1 receptor antagonist L-732,138 on such cells is unknown. The aim of this study was to demonstrate an antitumor action of L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679). We found that L-732,138 elicits cell growth inhibition in a concentration dependent manner in the melanoma cells studied. Moreover, L-732,138 blocks SP mitogen stimulation. The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis. These findings indicate that the NK-1 receptor antagonist L-732,138 could be a new antitumor agent in the treatment of human melanoma.
Keywords: melanoma; NK-1 receptor antagonist; L-732,138; antitumor; apoptosis melanoma; NK-1 receptor antagonist; L-732,138; antitumor; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Muñoz, M.; Rosso, M.; González-Ortega, A.; Coveñas, R. The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines. Cancers 2010, 2, 611-623.

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