Cancers 2010, 2(2), 611-623; doi:10.3390/cancers2020611
Article

The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines

1,* email, 1email, 1email and 2email
Received: 17 March 2010; in revised form: 14 April 2010 / Accepted: 19 April 2010 / Published: 20 April 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: It has been recently demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonists induce cell proliferation and cell inhibition in human melanoma cells, respectively. However, the antitumor action of the NK-1 receptor antagonist L-732,138 on such cells is unknown. The aim of this study was to demonstrate an antitumor action of L-732,138 against three human melanoma cell lines (COLO 858, MEL HO, COLO 679). We found that L-732,138 elicits cell growth inhibition in a concentration dependent manner in the melanoma cells studied. Moreover, L-732,138 blocks SP mitogen stimulation. The specific antitumor action of L-732,138 occurred through the NK-1 receptor and melanoma cell death was by apoptosis. These findings indicate that the NK-1 receptor antagonist L-732,138 could be a new antitumor agent in the treatment of human melanoma.
Keywords: melanoma; NK-1 receptor antagonist; L-732,138; antitumor; apoptosis
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MDPI and ACS Style

Muñoz, M.; Rosso, M.; González-Ortega, A.; Coveñas, R. The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines. Cancers 2010, 2, 611-623.

AMA Style

Muñoz M, Rosso M, González-Ortega A, Coveñas R. The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines. Cancers. 2010; 2(2):611-623.

Chicago/Turabian Style

Muñoz, Miguel; Rosso, Marisa; González-Ortega, Ana; Coveñas, Rafael. 2010. "The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines." Cancers 2, no. 2: 611-623.

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