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Cancers 2010, 2(2), 567-591;

Role of Uncoupling Proteins in Cancer

Grupo Multidisciplinar de Oncología Traslacional, Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears/Cra. Valldemossa km 7.5, E-07122, Palma de Mallorca, Illes Balears, Spain
Author to whom correspondence should be addressed.
Received: 4 March 2010 / Revised: 31 March 2010 / Accepted: 12 April 2010 / Published: 16 April 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
View Full-Text   |   Download PDF [856 KB, uploaded 16 April 2010]   |  


Uncoupling proteins (UCPs) are a family of inner mitochondrial membrane proteins whose function is to allow the re-entry of protons to the mitochondrial matrix, by dissipating the proton gradient and, subsequently, decreasing membrane potential and production of reactive oxygen species (ROS). Due to their pivotal role in the intersection between energy efficiency and oxidative stress, UCPs are being investigated for a potential role in cancer. In this review we compile the latest evidence showing a link between uncoupling and the carcinogenic process, paying special attention to their involvement in cancer initiation, progression and drug chemoresistance. View Full-Text
Keywords: uncoupling proteins; cancer; proton leak; mitochondria; chemoresistance; carcinogenesis; oxidative stress uncoupling proteins; cancer; proton leak; mitochondria; chemoresistance; carcinogenesis; oxidative stress

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Valle, A.; Oliver, J.; Roca, P. Role of Uncoupling Proteins in Cancer. Cancers 2010, 2, 567-591.

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