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Cancers 2010, 2(2), 1288-1311; doi:10.3390/cancers2021288
Review
Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin
Lara Gibellini
, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza*
, Marcello Pinti, Milena Nasi, Sara De Biasi, Erika Roat, Linda Bertoncelli and Andrea Cossarizza*
Department of Biomedical Sciences, School of Medicine, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy
* Author to whom correspondence should be addressed.
Received: 6 May 2010; in revised form: 8 June 2010 / Accepted: 11 June 2010 / Published: 14 June 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
Download PDF Full-Text [402 KB, uploaded 14 June 2010 10:05 CEST]
Abstract: A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.
Keywords: cancer; reactive oxygen species; redox homeostasis; flavonoids; quercetin
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MDPI and ACS Style
Gibellini, L.; Pinti, M.; Nasi, M.; De Biasi, S.; Roat, E.; Bertoncelli, L.; Cossarizza, A. Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers 2010, 2, 1288-1311.
AMA StyleGibellini L, Pinti M, Nasi M, De Biasi S, Roat E, Bertoncelli L, Cossarizza A. Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers. 2010; 2(2):1288-1311.
Chicago/Turabian StyleGibellini, Lara; Pinti, Marcello; Nasi, Milena; De Biasi, Sara; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea. 2010. "Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin." Cancers 2, no. 2: 1288-1311.