Cancers 2010, 2(2), 1288-1311; doi:10.3390/cancers2021288
Review

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

email, email, email, email, email, email and * email
Received: 6 May 2010; in revised form: 8 June 2010 / Accepted: 11 June 2010 / Published: 14 June 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive oxygen species (ROS) than normal cells, and ROS are, in turn, responsible for the maintenance of the cancer phenotype. Persistent ROS stress may induce adaptive stress responses, enabling cancer cells to survive with high levels of ROS and maintain cellular viability. However, excessive ROS levels render cancer cells highly susceptible to quercetin, one of the main dietary flavonoids. Quercetin depletes intracellular glutathione and increases intracellular ROS to a level that can cause cell death.
Keywords: cancer; reactive oxygen species; redox homeostasis; flavonoids; quercetin
PDF Full-text Download PDF Full-Text [402 KB, uploaded 14 June 2010 10:05 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Gibellini, L.; Pinti, M.; Nasi, M.; De Biasi, S.; Roat, E.; Bertoncelli, L.; Cossarizza, A. Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers 2010, 2, 1288-1311.

AMA Style

Gibellini L, Pinti M, Nasi M, De Biasi S, Roat E, Bertoncelli L, Cossarizza A. Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin. Cancers. 2010; 2(2):1288-1311.

Chicago/Turabian Style

Gibellini, Lara; Pinti, Marcello; Nasi, Milena; De Biasi, Sara; Roat, Erika; Bertoncelli, Linda; Cossarizza, Andrea. 2010. "Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin." Cancers 2, no. 2: 1288-1311.

Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert