Next Article in Journal
Previous Article in Journal
Previous Article in Special Issue
Cancers 2010, 2(2), 1354-1378; doi:10.3390/cancers2021354
Review

The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells

1
, 2
 and 1,*
Received: 7 June 2010; in revised form: 18 June 2010 / Accepted: 21 June 2010 / Published: 21 June 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
View Full-Text   |   Download PDF [579 KB, uploaded 21 June 2010]   |   Browse Figures
Abstract: Reactive oxygen species (ROS) signaling has recently sparked a surge of interest as being the molecular underpinning for cancer cell survival, but the precise mechanisms involved have not been completely elucidated. This review covers the possible roles of two ROS-induced transcription factors, Nrf1 and Nrf2, and the antioxidant proteins peroxiredoxin-1 (Prx-1) and Thioredoxin-1 (Txn-1) in modulating AR expression and signaling in aggressive prostate cancer (PCa) cells. In androgen independent (AI) C4-2B cells, in comparison to the parental androgen dependent (AD) LNCaP cells, we present evidence of high Nrf1 and Prx-1 expression and low Nrf2 expression in these aggressive PCa cells. Furthermore, in DHT treated C4-2B cells, increased expression of the p65 (active) isoform of Nrf1 correlated with enhanced AR transactivation. Our findings implicate a crucial balance of Nrf1 and Nrf2 signaling in regulating AR activity in AI-PCa cells. Here we will discuss how understanding the mechanisms by which oxidative stress may affect AR signaling may aid in developing novel therapies for AI-PCa.
Keywords: Nrf1 (NF-E2 related factor-1); Nrf2 (NF-E2 related factor-2); prostate cancer; oxidative stress; androgen independence; androgen deprivation therapy; reactive oxygen species (ROS); androgen receptor (AR); di-hydrotestosterone (DHT) Nrf1 (NF-E2 related factor-1); Nrf2 (NF-E2 related factor-2); prostate cancer; oxidative stress; androgen independence; androgen deprivation therapy; reactive oxygen species (ROS); androgen receptor (AR); di-hydrotestosterone (DHT)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Schultz, M.A.; Abdel-Mageed, A.B.; Mondal, D. The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells. Cancers 2010, 2, 1354-1378.

AMA Style

Schultz MA, Abdel-Mageed AB, Mondal D. The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells. Cancers. 2010; 2(2):1354-1378.

Chicago/Turabian Style

Schultz, Michelle A.; Abdel-Mageed, Asim B.; Mondal, Debasis. 2010. "The Nrf1 and Nrf2 Balance in Oxidative Stress Regulation and Androgen Signaling in Prostate Cancer Cells." Cancers 2, no. 2: 1354-1378.



Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert