Cancers 2010, 2(2), 1013-1026; doi:10.3390/cancers2021013
Review

Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress

1email, 2email, 2email and 2,* email
Received: 8 April 2010; in revised form: 14 May 2010 / Accepted: 17 May 2010 / Published: 26 May 2010
(This article belongs to the Special Issue Oxidative Stress and Cancer)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cannabinoids, the active components of Cannabis sativa, have been shown to exert antiproliferative and proapoptotic effects on a wide spectrum of tumor cells and tissues. Of interest, cannabinoids have displayed great potency in reducing the growth of glioma tumors, one of the most aggressive CNS tumors, either in vitro or in animal experimental models curbing the growth of xenografts generated by subcutaneous or intrathecal injection of glioma cells in immune-deficient mice. Cannabinoids appear to be selective antitumoral agents as they kill glioma cells without affecting the viability of non-transformed cells. This review will summarize the anti-cancer properties that cannabinoids exert on gliomas and discuss their potential action mechanisms that appear complex, involving modulation of multiple key cell signaling pathways and induction of oxidative stress in glioma cells.
Keywords: cannabinoids; gliomas; apoptosis; cellular mechanism; oxidative stress
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MDPI and ACS Style

Massi, P.; Valenti, M.; Solinas, M.; Parolaro, D. Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress. Cancers 2010, 2, 1013-1026.

AMA Style

Massi P, Valenti M, Solinas M, Parolaro D. Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress. Cancers. 2010; 2(2):1013-1026.

Chicago/Turabian Style

Massi, Paola; Valenti, Marta; Solinas, Marta; Parolaro, Daniela. 2010. "Molecular Mechanisms Involved in the Antitumor Activity of Cannabinoids on Gliomas: Role for Oxidative Stress." Cancers 2, no. 2: 1013-1026.

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