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Cancers 2010, 2(2), 1312-1327; doi:10.3390/cancers2021312

Serum Biomarkers for Early Detection of Gynecologic Cancers

* ,
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 8 March 2010 / Revised: 31 May 2010 / Accepted: 3 June 2010 / Published: 14 June 2010
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Ovarian, endometrial, and cervical cancers are three of the most common malignancies of the female reproductive organs. CA 125, historically the most reliable serum marker for ovarian cancer, is elevated in 50% of early-stage ovarian tumors. For endometrial cancers, there are no established serum markers. SCC, which is the best studied serum marker for squamous cell carcinomas, has been unreliable; SCC is elevated in cervical squamous cell carcinomas ranging from 28–85% of the time. Recent proteomics-based analyses show great promise for the discovery of new and more useful biomarkers. In this review, we will discuss the currently utilized serum tumor markers for gynecologic cancers and the novel biomarkers that are now under investigation.
Keywords: ovarian; endometrial; cervical; cancer; serum; tumor marker; CA 125; SCC; proteomics; biomarkers ovarian; endometrial; cervical; cancer; serum; tumor marker; CA 125; SCC; proteomics; biomarkers
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ueda, Y.; Enomoto, T.; Kimura, T.; Miyatake, T.; Yoshino, K.; Fujita, M.; Kimura, T. Serum Biomarkers for Early Detection of Gynecologic Cancers. Cancers 2010, 2, 1312-1327.

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