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Micromachines 2018, 9(1), 28; doi:10.3390/mi9010028

Design and Near-Infrared Actuation of a Gold Nanorod–Polymer Microelectromechanical Device for On-Demand Drug Delivery

1
Faculty of Pharmaceutical Sciences, University of British Columbia, 2045 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada
2
Department of Mechanical Engineering, University of British Columbia, 6250 Applied Science, Vancouver, BC V6T 1Z4, Canada
*
Author to whom correspondence should be addressed.
Received: 18 December 2017 / Revised: 7 January 2018 / Accepted: 11 January 2018 / Published: 13 January 2018
(This article belongs to the Special Issue Biomedical Microdevices: Design, Fabrication and Application)
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Abstract

Polymeric drug delivery systems usually deliver drugs by diffusion with an initial burst of release followed by a slower prolonged release phase. An optimal system would release exact doses of drugs using an on-demand external actuation system. The purpose of this study was to design and characterize a novel drug-delivery device that utilizes near infrared (NIR 800 nm) laser-actuated drug release. The device was constructed from biocompatible polymers comprising a reservoir of drug covered by an elastic perforated diaphragm composed of a bilayer of two polymers with different thermal expansion coefficients (ethylenevinylacetate (EVA) and polydimethylsiloxane (PDMS) containing gold nanoparticles). Upon illumination with a NIR laser, the gold nanoparticles rapidly heated the bilayer resulting in bending and a drug-pumping action through the perforated bilayer, following sequential laser-actuation cycles. Devices filled with the anti-proliferative drug docetaxel were seen to release only small amounts of drug by diffusion but to release large and reproducible amounts of drug over 20 s laser-actuation periods. Because NIR 800 nm is tissue-penetrating without heating tissue, suitable geometry drug-delivery devices might be implanted in the body to be actuated by an externally applied NIR laser to allow for on-demand exact drug dosing in vivo. View Full-Text
Keywords: microelectromechanical systems (MEMS); near infrared (NIR) laser actuation; drug-release device; docetaxel; nanorod microelectromechanical systems (MEMS); near infrared (NIR) laser actuation; drug-release device; docetaxel; nanorod
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jackson, J.; Chen, A.; Zhang, H.; Burt, H.; Chiao, M. Design and Near-Infrared Actuation of a Gold Nanorod–Polymer Microelectromechanical Device for On-Demand Drug Delivery. Micromachines 2018, 9, 28.

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