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Micromachines 2017, 8(11), 329; doi:10.3390/mi8110329

Label-Free Monitoring of Diffusion in Microfluidics

Department of Micro- and Nanotechnology, Technical University of Denmark, Kongens Lyngby 2800, Denmark
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Received: 12 October 2017 / Revised: 3 November 2017 / Accepted: 6 November 2017 / Published: 9 November 2017
(This article belongs to the Special Issue Optofluidics: From Fundamental Research to Applications)
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Abstract

Label-free, real-time detection of concentration gradients is demonstrated in a microfluidic H-filter, using an integrated photonic crystal slab sensor to monitor sample refractive index with spatial resolution. The recorded diffusion profiles reveal root-mean-square diffusion lengths for non-fluorescing and non-absorbing molecules, both small (glucose, 180 Da) and large (bovine serum albumin, 67 kDa). View Full-Text
Keywords: optofluidics; microfluidics; diffusion; convection; mixing; refractive index; label-free optofluidics; microfluidics; diffusion; convection; mixing; refractive index; label-free
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Tølbøl Sørensen, K.; Kristensen, A. Label-Free Monitoring of Diffusion in Microfluidics. Micromachines 2017, 8, 329.

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