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Micromachines 2017, 8(11), 328; doi:10.3390/mi8110328

Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding

1
IFN CNR, Institute for Photonics and Nanotechnologies, National Research Council, Piazza Leonardo da Vinci, 32, 20133 Milan, Italy
2
ITIA CNR, Institute of Industrial Technology and Automation, National Research Council, Via P. Lembo 38F, 70124 Bari, Italy
3
IFN CNR, Institute for Photonics and Nanotechnologies, National Research Council, Via Amendola 173, 70126 Bari, Italy
4
ISASI CNR, Institute of Applied Sciences & Intelligent Systems “E. Caianiello”, Via Torre Bianca—Istituto Marino Pad. 4 Mortelle, 98164 Messina, Italy
5
ISASI CNR, Institute of Applied Sciences & Intelligent Systems “E. Caianiello”, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
6
ITIA CNR, Institute of Industrial Technology and Automation, National Research Council, Via A. Corti 12, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 31 October 2017 / Accepted: 3 November 2017 / Published: 7 November 2017
(This article belongs to the Special Issue Ultrafast Laser Fabrication for Lab-on-a-Chip)
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Abstract

We have introduced a new hybrid fabrication method for lab-on-a-chip devices through the combination of femtosecond laser micromachining and removable insert micro-injection molding. This method is particularly suited for the fast prototyping of new devices, while maintaining a competitive low cost. To demonstrate the effectiveness of our approach, we designed, fabricated, and tested a completely integrated flow cytometer coupled to a portable media device. The system operation was tested with fluorescent plastic micro-bead solutions ranging from 100 beads/μL to 500 beads/μL. We demonstrated that this hybrid lab-on-a-chip fabrication technology is suitable for producing low-cost and portable biological microsystems and for effectively bridging the gap between new device concepts and their mass production. View Full-Text
Keywords: lab-on-a-chip; micro-injection-molding; femtosecond laser micromachining; fluorescent cytometry; cell phone lab-on-a-chip; micro-injection-molding; femtosecond laser micromachining; fluorescent cytometry; cell phone
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Martínez Vázquez, R.; Trotta, G.; Volpe, A.; Bernava, G.; Basile, V.; Paturzo, M.; Ferraro, P.; Ancona, A.; Fassi, I.; Osellame, R. Rapid Prototyping of Plastic Lab-on-a-Chip by Femtosecond Laser Micromachining and Removable Insert Microinjection Molding. Micromachines 2017, 8, 328.

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