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Micromachines 2016, 7(9), 156; doi:10.3390/mi7090156

Enhanced Throughput for Electrokinetic Manipulation of Particles and Cells in a Stacked Microfluidic Device

1
School of Engineering, Anhui Agricultural University, Hefei 230036, China
2
Department of Mechanical Engineering, Clemson University, Clemson, SC 29634-0921, USA
3
Department of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Shizhi Qian and Wen Jung Li
Received: 27 July 2016 / Revised: 23 August 2016 / Accepted: 29 August 2016 / Published: 1 September 2016
(This article belongs to the Special Issue Micro/Nano-Chip Electrokinetics)
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Abstract

Electrokinetic manipulation refers to the control of particle and cell motions using an electric field. It is an efficient technique for microfluidic applications with the ease of operation and integration. It, however, suffers from an intrinsic drawback of low throughput due to the linear dependence of the typically very low fluid permittivity. We demonstrate in this work a significantly enhanced throughput for electrokinetic manipulation of particles and cells by the use of multiple parallel microchannels in a two-layer stacked microfluidic device. The fabrication of this device is simple without the need of a precise alignment of the two layers. The number of layers and the number of microchannels in each layer can thus be further increased for a potentially high throughput electrokinetic particle and cell manipulations. View Full-Text
Keywords: dielectrophoresis; reservoir; particle separation; particle concentration; parallel operation dielectrophoresis; reservoir; particle separation; particle concentration; parallel operation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, L.; Patel, S.H.; Johnson, M.; Kale, A.; Raval, Y.; Tzeng, T.-R.; Xuan, X. Enhanced Throughput for Electrokinetic Manipulation of Particles and Cells in a Stacked Microfluidic Device. Micromachines 2016, 7, 156.

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