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Micromachines 2016, 7(3), 45; doi:10.3390/mi7030045

Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform

1
Den—Service d’Etudes Analytiques et de Réactivité des Surfaces (SEARS), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France
2
MMBM Group, Institut Curie Research Center, CNRS UMR 168, F-75005 Paris, France
3
Den—Service d’Etude du Comportement des Radionucléides (SECR), CEA, Université Paris-Saclay, F-91191 Gif sur Yvette, France
*
Author to whom correspondence should be addressed.
Academic Editor: Marc Madou
Received: 4 February 2016 / Revised: 2 March 2016 / Accepted: 7 March 2016 / Published: 10 March 2016
(This article belongs to the Special Issue Centrifugal (Compact-Disc) Microfluidics for Extreme POC)
View Full-Text   |   Download PDF [7035 KB, uploaded 10 March 2016]   |  

Abstract

The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the in situ light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation module in centrifugal microsystem devices. This paper presents a systematic study of the synthesis of the polymeric porous monolith poly(ethylene glycol methacrylate-co-allyl methacrylate) used as a solid-phase support and the versatile and robust photografting process of the monolith based on thiol-ene click chemistry. The polymerization reaction is investigated, varying the formulation of the polymerisable mixture. The robustness of the stationary phase was tested in concentrated nitric acid. Thanks to their unique “easy-to-use” features, centrifugal microfluidic platforms are potential successful candidates for the downscaling of chromatographic separation of radioactive samples (automation, multiplexing, easy integration in glove-boxes environment, and low cost of maintenance). View Full-Text
Keywords: nitric acid; radiochemistry; monolith; thiol-ene; click-chemistry; chromatography; anion-exchanger; nuclear spent fuel nitric acid; radiochemistry; monolith; thiol-ene; click-chemistry; chromatography; anion-exchanger; nuclear spent fuel
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Losno, M.; Ferrante, I.; Brennetot, R.; Varlet, J.; Blanc, C.; Grenut, B.; Amblard, E.; Descroix, S.; Mariet, C. Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform. Micromachines 2016, 7, 45.

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