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Micromachines 2016, 7(3), 46; doi:10.3390/mi7030046

Microstructure-Enhanced Liquid–Liquid Extraction in a Real-Time Fluorescence Detection Microfluidic Chip

1
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China
2
National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, China
This paper is an extended version of our paper presented in the 17th Annual Conference of the Chinese Society of Micro-Nano Technology, Shanghai, China, 11–14 October 2015.
*
Authors to whom correspondence should be addressed.
Academic Editor: Jeong-Bong Lee
Received: 25 January 2016 / Revised: 27 February 2016 / Accepted: 8 March 2016 / Published: 10 March 2016
(This article belongs to the Collection Lab-on-a-Chip)
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Abstract

Microfluidic system is widely employed in the detection of environmental contaminants and biological specimens. One of the critical issues which limits the applications of microfluidic chips is the limit of detection of trace specimens. Liquid–liquid extraction is of great importance in the preprocessing in microfluidic devices. In this paper, we developed a real-time fluorescence detection microfluidic chip combined with a microstructure-enhanced liquid–liquid laminar extraction technique, which concentrated the trace compound and realized real-time monitoring. Auxiliary microstructures integrated in the microfluidic chip were applied to increase the extraction efficiency, which was proved by the FEM (finite element method) simulation as well. A common fluorescence probe, Rhodamine 6G (Rh6g), was used in the experiment to demonstrate the performance of the microfluidic system. It revealed that the liquid–liquid laminar extraction combined with auxiliary microstructures of a cross shape was an effective method for enrichment. The efficiency of microstructure-enhanced liquid–liquid extraction was increased by 350% compared to the traditional laminar flow extraction. View Full-Text
Keywords: microfluidic chip; liquid–liquid extraction; lithography; fluorescence detection microfluidic chip; liquid–liquid extraction; lithography; fluorescence detection
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xiong, P.; Chen, X.; Xiong, Y.; Liu, G.; Tian, Y. Microstructure-Enhanced Liquid–Liquid Extraction in a Real-Time Fluorescence Detection Microfluidic Chip . Micromachines 2016, 7, 46.

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