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Micromachines 2014, 5(4), 868-885; doi:10.3390/mi5040868

Mechanical Analysis of a Pneumatically Actuated Concentric Double-Shell Structure for Cell Stretching

1
Department of Automation Science and Engineering, Tampere University of Technology, Tampere 33720, Finland
2
BioMediTech Institute, Biokatu 10, Tampere 33520, Finland
3
Department of Mechanics and Design, Tampere University of Technology, Tampere 33720, Finland
*
Author to whom correspondence should be addressed.
Received: 8 July 2014 / Revised: 19 September 2014 / Accepted: 1 October 2014 / Published: 16 October 2014
(This article belongs to the Special Issue Biomedical Microdevices)
View Full-Text   |   Download PDF [5682 KB, uploaded 16 October 2014]   |  

Abstract

An available novel system for studying the cellular mechanobiology applies an equiaxial strain field to cells cultured on a PolyDiMethylSiloxane (PDMS) substrate membrane, which is stretched over the deformation of a cylindrical shell. In its application of in vitro cell culture, the in-plane strain of the substrate membrane provides mechanical stimulation to cells, and out-of-plane displacement plays an important role in monitoring the cells by a microscope. However, no analysis of the parameters has been reported yet. Therefore, in this paper, we employ analytical and computational models to investigate the mechanical behavior of the device, in terms of in-plane strain and out-of-plane displacement of the substrate membrane. As a result, mathematical descriptions are given, which are not only for quantitatively determining the applied load, but also provide the theoretical basis for the researchers to carry out structural modification, according to their needs in specific cell culture experiments. Furthermore, by computational study, the elastic modulus of PDMS is determined to allow the mechanical behavior analysis of a fabricated device. Finally, compared to the experimental results of characterizing a fabricated device, good agreement is obtained between the predicted and experimental results. View Full-Text
Keywords: finite element; computational modeling; mechanical stimulation device; mechanobiology; substrate strain finite element; computational modeling; mechanical stimulation device; mechanobiology; substrate strain
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, F.; Kreutzer, J.; Pajunen, S.; Kallio, P. Mechanical Analysis of a Pneumatically Actuated Concentric Double-Shell Structure for Cell Stretching. Micromachines 2014, 5, 868-885.

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