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Review on Impedance Detection of Cellular Responses in Micro/Nano Environment
Graduate Institute of Medical Mechatronics, Department of Mechanical Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, 333 Taiwan
Received: 4 September 2013; in revised form: 30 October 2013 / Accepted: 28 December 2013 / Published: 7 January 2014
Abstract: In general, cell culture-based assays, investigations of cell number, viability, and metabolic activities during culture periods, are commonly performed to study the cellular responses under various culture conditions explored. Quantification of cell numbers can provide the information of cell proliferation. Cell viability study can understand the percentage of cell death under a specific tested substance. Monitoring of the metabolic activities is an important index for the study of cell physiology. Based on the development of microfluidic technology, microfluidic systems incorporated with impedance measurement technique, have been reported as a new analytical approach for cell culture-based assays. The aim of this article is to review recent developments on the impedance detection of cellular responses in micro/nano environment. These techniques provide an effective and efficient technique for cell culture-based assays.
Keywords: impedance measurement; cell culture; cellular responses; microfluidics
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MDPI and ACS Style
Lei, K.F. Review on Impedance Detection of Cellular Responses in Micro/Nano Environment. Micromachines 2014, 5, 1-12.
Lei KF. Review on Impedance Detection of Cellular Responses in Micro/Nano Environment. Micromachines. 2014; 5(1):1-12.
Lei, Kin F. 2014. "Review on Impedance Detection of Cellular Responses in Micro/Nano Environment." Micromachines 5, no. 1: 1-12.