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Micromachines 2014, 5(1), 1-12; doi:10.3390/mi5010001
Review

Review on Impedance Detection of Cellular Responses in Micro/Nano Environment

Graduate Institute of Medical Mechatronics, Department of Mechanical Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan
Received: 4 September 2013 / Revised: 30 October 2013 / Accepted: 28 December 2013 / Published: 7 January 2014
(This article belongs to the Special Issue Micro/Nanofluidic Devices for Single Cell Analysis)
View Full-Text   |   Download PDF [420 KB, 13 January 2014; original version 7 January 2014]   |   Browse Figures

Abstract

In general, cell culture-based assays, investigations of cell number, viability, and metabolic activities during culture periods, are commonly performed to study the cellular responses under various culture conditions explored. Quantification of cell numbers can provide the information of cell proliferation. Cell viability study can understand the percentage of cell death under a specific tested substance. Monitoring of the metabolic activities is an important index for the study of cell physiology. Based on the development of microfluidic technology, microfluidic systems incorporated with impedance measurement technique, have been reported as a new analytical approach for cell culture-based assays. The aim of this article is to review recent developments on the impedance detection of cellular responses in micro/nano environment. These techniques provide an effective and efficient technique for cell culture-based assays.
Keywords: impedance measurement; cell culture; cellular responses; microfluidics impedance measurement; cell culture; cellular responses; microfluidics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lei, K.F. Review on Impedance Detection of Cellular Responses in Micro/Nano Environment. Micromachines 2014, 5, 1-12.

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