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Toxins 2015, 7(5), 1749-1764; doi:10.3390/toxins7051749

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

1
Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China
2
Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China
3
Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Azzam A. Maghazachi
Received: 10 April 2015 / Revised: 5 May 2015 / Accepted: 5 May 2015 / Published: 19 May 2015
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
View Full-Text   |   Download PDF [983 KB, uploaded 19 May 2015]   |  

Abstract

Autoimmune diseases are usually accompanied by tissue injury caused by autoantigen-specific T-cells. KV1.3 channels participate in modulating calcium signaling to induce T-cell proliferation, immune activation and cytokine production. Effector memory T (TEM)-cells, which play major roles in many autoimmune diseases, are controlled by blocking KV1.3 channels on the membrane. Toxins derived from animal venoms have been found to selectively target a variety of ion channels, including KV1.3. By blocking the KV1.3 channel, these toxins are able to suppress the activation and proliferation of TEM cells and may improve TEM cell-mediated autoimmune diseases, such as multiple sclerosis and type I diabetes mellitus. View Full-Text
Keywords: toxins; KV1.3 channel; effector memory T-cell; autoimmune diseases toxins; KV1.3 channel; effector memory T-cell; autoimmune diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, Y.; Huang, J.; Yuan, X.; Peng, B.; Liu, W.; Han, S.; He, X. Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases. Toxins 2015, 7, 1749-1764.

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