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Toxins 2015, 7(1), 129-137; doi:10.3390/toxins7010129

Increased Circulating Levels of Vitamin D Binding Protein in MS Patients

Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome 00161, Italy
Multiple Sclerosis Center, Sapienza University of Rome, Rome 00161, Italy
Centre for Experimental Neurological Therapies (CENTERS) Department of Neurosciences, Mental Health and Sensory Organs Sapienza University, S. Andrea Hospital-site, Rome 00161, Italy
National Center for Epidemiology, Surveillance and Health Promotion, Istituto Superiore di Sanità, Rome 00161, Italy
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Azzam A. Maghazachi
Received: 14 November 2014 / Accepted: 5 January 2015 / Published: 13 January 2015
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
View Full-Text   |   Download PDF [474 KB, uploaded 13 January 2015]   |  


Vitamin D (vitD) low status is currently considered a main environmental factor in multiple sclerosis (MS) etiology and pathogenesis. VitD and its metabolites are highly hydrophobic and circulate mostly bound to the vitamin D binding protein (DBP) and with lower affinity to albumin, while less than 1% are in a free form. The aim of this study was to investigate whether the circulating levels of either of the two vitD plasma carriers and/or their relationship are altered in MS. We measured DBP and albumin plasma levels in 28 MS patients and 24 healthy controls. MS patients were found to have higher DBP levels than healthy subjects. Concomitant interferon beta therapy did not influence DBP concentration, and the difference with the control group was significant in both females and males. No significant correlation between DBP and albumin levels was observed either in healthy controls or in patients. These observations suggest the involvement of DBP in the patho-physiology of MS. View Full-Text
Keywords: vitamin D binding protein; albumin; relapsing/remitting multiple sclerosis; beta-interferon; immunology; vitamin D vitamin D binding protein; albumin; relapsing/remitting multiple sclerosis; beta-interferon; immunology; vitamin D

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rinaldi, A.O.; Sanseverino, I.; Purificato, C.; Cortese, A.; Mechelli, R.; Francisci, S.; Salvetti, M.; Millefiorini, E.; Gessani, S.; Gauzzi, M.C. Increased Circulating Levels of Vitamin D Binding Protein in MS Patients. Toxins 2015, 7, 129-137.

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