Next Article in Journal
Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A
Next Article in Special Issue
Dendritic Cell Protection from Cisplatin Nephrotoxicity Is Independent of Neutrophils
Previous Article in Journal
Honeybee (Apis mellifera) Venom Reinforces Viral Clearance during the Early Stage of Infection with Porcine Reproductive and Respiratory Syndrome Virus through the Up-Regulation of Th1-Specific Immune Responses
Previous Article in Special Issue
Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases
Article Menu

Export Article

Open AccessReview
Toxins 2015, 7(6), 1854-1881; doi:10.3390/toxins7061854

Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs

Department of Biotechnology, Israel Institute for Biological Research, Ness Ziona 7410001, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Azzam A. Maghazachi
Received: 5 March 2015 / Revised: 7 May 2015 / Accepted: 19 May 2015 / Published: 29 May 2015
(This article belongs to the Collection Toxicity and Therapeutic Interventions in the Immune System)
View Full-Text   |   Download PDF [852 KB, uploaded 29 May 2015]   |  

Abstract

Monoclonal antibodies (MAbs) are among the fastest-growing therapeutics and are being developed for a broad range of indications, including the neutralization of toxins, bacteria and viruses. Nevertheless, MAbs potency is still relatively low when compared to conventional polyclonal Ab preparations. Moreover, the efficacy of an individual neutralizing MAb may significantly be hampered by the potential absence or modification of its target epitope in a mutant or subtype of the infectious agent. These limitations of individual neutralizing MAbs can be overcome by using oligoclonal combinations of several MAbs with different specificities to the target antigen. Studies conducted in our lab and by others show that such combined MAb preparation may present substantial synergy in its potency over the calculated additive potency of its individual MAb components. Moreover, oligoclonal preparation is expected to be better suited to compensating for reduced efficacy due to epitope variation. In this review, the synergistic neutralization properties of combined oligoclonal Ab preparations are described. The effect of Ab affinity, autologous Fc fraction, and targeting a critical number of epitopes, as well as the unexpected contribution of non-neutralizing clones to the synergistic neutralizing effect are presented and discussed. View Full-Text
Keywords: MAbs; oligoclonal; combination; neutralization; synergism; toxin MAbs; oligoclonal; combination; neutralization; synergism; toxin
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Diamant, E.; Torgeman, A.; Ozeri, E.; Zichel, R. Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs. Toxins 2015, 7, 1854-1881.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxins EISSN 2072-6651 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top