Open AccessThis article is
- freely available
Toxins 2012, 4(2), 139-156; doi:10.3390/toxins4020139
Host-Defense Activities of Cyclotides
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
Received: 22 November 2011; in revised form: 25 January 2012 / Accepted: 31 January 2012 / Published: 15 February 2012
(This article belongs to the Special Issue Insecticidal Toxins)
Download PDF Full-Text [1267 KB, Updated Version, uploaded 22 February 2012 17:12 CET]
The original version is still available [1267 KB, uploaded 15 February 2012 09:02 CET]
Abstract: Cyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine knot arrangement of three conserved disulfide bonds. This article provides an overview of the reported pesticidal or toxic activities of cyclotides, discusses a possible common mechanism of action involving disruption of biological membranes in pest species, and describes methods that can be used to produce cyclotides for potential applications as novel pesticidal agents.
Keywords: circular protein; cyclic peptide; cyclotide; cystine knot; insecticide; kalata B1
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
MDPI and ACS Style
Craik, D.J. Host-Defense Activities of Cyclotides. Toxins 2012, 4, 139-156.AMA Style
Craik DJ. Host-Defense Activities of Cyclotides. Toxins. 2012; 4(2):139-156.Chicago/Turabian Style
Craik, David J. 2012. "Host-Defense Activities of Cyclotides." Toxins 4, no. 2: 139-156.