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Host-Defense Activities of Cyclotides
AbstractCyclotides are plant mini-proteins whose natural function is thought to be to protect plants from pest or pathogens, particularly insect pests. They are approximately 30 amino acids in size and are characterized by a cyclic peptide backbone and a cystine knot arrangement of three conserved disulfide bonds. This article provides an overview of the reported pesticidal or toxic activities of cyclotides, discusses a possible common mechanism of action involving disruption of biological membranes in pest species, and describes methods that can be used to produce cyclotides for potential applications as novel pesticidal agents.
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Craik, D.J. Host-Defense Activities of Cyclotides. Toxins 2012, 4, 139-156.View more citation formats
Craik DJ. Host-Defense Activities of Cyclotides. Toxins. 2012; 4(2):139-156.Chicago/Turabian Style
Craik, David J. 2012. "Host-Defense Activities of Cyclotides." Toxins 4, no. 2: 139-156.