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Botulinum Neurotoxin for Pain Management: Insights from Animal Models
Toxins 2011, 3(1), 63-81; doi:10.3390/toxins3010063

Towards New Uses of Botulinum Toxin as a Novel Therapeutic Tool

*  and
Biologicals Science and Technology, Ipsen Biopharm Limited, Ash Road North, Wrexham, LL13 9UF, UK
* Author to whom correspondence should be addressed.
Received: 7 December 2010 / Revised: 3 January 2011 / Accepted: 4 January 2011 / Published: 12 January 2011
(This article belongs to the Special Issue Toxins as Therapeutics)
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The uses of botulinum toxin in the fields of neurology, ophthalmology, urology, rehabilitation medicine and aesthetic applications have been revolutionary for the treatment of patients. This non-invasive therapeutic has continually been developed since first discovered in the 1970s as a new approach to what were previously surgical treatments. As these applications develop, so also the molecules are developing into tools with new therapeutic properties in specific clinical areas. This review examines how the botulinum toxin molecule is being adapted to new therapeutic uses and also how new areas of use for the existing molecules are being identified. Prospects for future developments are also considered.
Keywords: clostridial neurotoxin; BoNT; engineering; targeting clostridial neurotoxin; BoNT; engineering; targeting
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pickett, A.; Perrow, K. Towards New Uses of Botulinum Toxin as a Novel Therapeutic Tool. Toxins 2011, 3, 63-81.

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