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Toxins 2010, 2(11), 2519-2583; doi:10.3390/toxins2112519
Review

Toxin-Based Therapeutic Approaches

 and *
Received: 14 October 2010; in revised form: 25 October 2010 / Accepted: 26 October 2010 / Published: 28 October 2010
(This article belongs to the Special Issue Toxins as Therapeutics)
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Abstract: Protein toxins confer a defense against predation/grazing or a superior pathogenic competence upon the producing organism. Such toxins have been perfected through evolution in poisonous animals/plants and pathogenic bacteria. Over the past five decades, a lot of effort has been invested in studying their mechanism of action, the way they contribute to pathogenicity and in the development of antidotes that neutralize their action. In parallel, many research groups turned to explore the pharmaceutical potential of such toxins when they are used to efficiently impair essential cellular processes and/or damage the integrity of their target cells. The following review summarizes major advances in the field of toxin based therapeutics and offers a comprehensive description of the mode of action of each applied toxin.
Keywords: toxins; targeting; pseudomonas exotoxin A; diphtheria toxin; ricin; anthrax; immunotoxins; suicide gene toxins; targeting; pseudomonas exotoxin A; diphtheria toxin; ricin; anthrax; immunotoxins; suicide gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Shapira, A.; Benhar, I. Toxin-Based Therapeutic Approaches. Toxins 2010, 2, 2519-2583.

AMA Style

Shapira A, Benhar I. Toxin-Based Therapeutic Approaches. Toxins. 2010; 2(11):2519-2583.

Chicago/Turabian Style

Shapira, Assaf; Benhar, Itai. 2010. "Toxin-Based Therapeutic Approaches." Toxins 2, no. 11: 2519-2583.



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