Vitamin D Every Day to Keep the Infection Away?
AbstractWithin the last decade, vitamin D has emerged as a central regulator of host defense against infections. In this regard, vitamin D triggers effective antimicrobial pathways against bacterial, fungal and viral pathogens in cells of the human innate immune system. However, vitamin D also mediates potent tolerogenic effects: it is generally believed that vitamin D attenuates inflammation and acquired immunity, and thus potentially limits collateral tissue damage. Nevertheless, several studies indicate that vitamin D promotes aspects of acquired host defense. Clinically, vitamin D deficiency has been associated with an increased risk for various infectious diseases in epidemiological studies; yet, robust data from controlled trials investigating the use of vitamin D as a preventive or therapeutic agent are missing. In this review, we summarize the current knowledge regarding the effect of vitamin D on innate and acquired host defense, and speculate on the difficulties to translate the available molecular medicine data into practical therapeutic or preventive recommendations. View Full-Text
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Kroner, J.C.; Sommer, A.; Fabri, M. Vitamin D Every Day to Keep the Infection Away? Nutrients 2015, 7, 4170-4188.
Kroner JC, Sommer A, Fabri M. Vitamin D Every Day to Keep the Infection Away? Nutrients. 2015; 7(6):4170-4188.Chicago/Turabian Style
Kroner, Juliana C.; Sommer, Andrea; Fabri, Mario. 2015. "Vitamin D Every Day to Keep the Infection Away?" Nutrients 7, no. 6: 4170-4188.